Archive June 2015

High Sugar and Fat Changes the Gut Microbiome and Cognitive Flexibility!

There is growing evidence that altering the microbiome can influence the brain and behavior, and therefore Western diets which are high in fat, sugars and refined carbohydrates may influence behavior and gut microbiota. Researchers led by Kathy Magnusson at Oregon State University with the Linus Pauling Institute conducted a study to determine whether diet-induced changes in the gut microbiota could contribute to alterations in anxiety, memory or cognitive flexibility (the ability to immediately adapt to changes such as how to get home if the road you use is closed and you need to find a new way home). Two month old male mice were randomly assigned high-fat, high-sugar or normal chow diets. Testing for long and short term memory and cognitive flexibility was conducted during weeks 5-6 post-diet change. While some similarities in microbiome alterations were seen in both the high-fat and high sugar diets (>Clostridiales), the percentage decreases in Bacteroidales were greater in the high-sugar group. The high-sugar group was significantly impaired in early development of a spatial bias for long-term memory, short-term memory and reversal training. The higher percentages of Clostridiales and lower expression of Bacteroidales in high-energy diets were related to poorer cognitive flexibility in the reversal trials, suggesting that changes in the microbiome can contribute to cognitive changes associated with the Western diet.

Magnusson KR, et al. Relationships between diet-related changes in the gut microbiome and cognitive flexibility. Neuroscience.2015 May 14;300: 128-140.


Glucosamine and Chondroitin for a longer life?

Glucosamine and chondroitin are primarily used for osteoarthritis and joint pain, with an estimated 7.4% of Americans (age 57-85) having used them in 2005-06. While studies of their efficacy have yielded inconsistent results, evidence from laboratory, animal, and a number of human studies suggest that glucosamine and chondroitin have anti-inflammatory properties which could reduce the risk of multiple diseases. Researchers evaluated whether use of glucosamine and chondroitin are associated with cause-specific and total mortality. The cohort study consisted of 77,510 participants, aged 50-76, who entered the cohort in 2000-2002. Participants were followed for mortality through 2008. They found that the current use of glucosamine, with or without chondroitin, was associated with a significant decreased risk of death from cancer, and with a large risk reduction for death from respiratory diseases. They concluded that use of glucosamine with or without chondroitin was associated with reduced total mortality, and with reductions of several broad causes of death.

AB Griffith, et al. Use of Glucosamine and Chondroitin in Relation to Mortality. Eur J Epidemiol. 2012 Aug; 27(8): 593-603.


Sculacia® Supplement FAQ

Why you may need Sculacia®: In recent years, the safety of pharmaceutical joint pain formulas has been questioned and has resulted in doctors looking for effective, natural answers to support their patients’ needs. Sculacia® is such a product. Supplying a patented, proprietary, all-natural blend of Sculletaria baicalensis and Acacia catechu herbal extracts, Sculacia® inhibits the cascade of pro-inflammatory mediators. The efficacy of the Sculacia® formula was established in a clinical double blind study, where significant improvement was documented for joint comfort, stiffness and function, as compared to placebo.

Why your healthcare practitioner recommends Sculacia®: Sculacia® is yet another fine example of the leading-edge nutritional supplements that are available exclusively from Biotics Research Corporation. The beneficial effects from taking Sculacia® will be noted by the end of the first bottle, and frequently they can be noted within the first few doses, making this an excellent product to use for those suffering from joint discomfort. Effective as a stand-alone product, Sculacia® is also an excellent adjunct to use with chondroprotective products such as ChondroSamine Plus® and Purified Chondroitin Sulfates, allowing patients to achieve significant impact almost immediately, while they wait for the accumulative effect of the chondroprotectives to be established. Sculacia® carries a low suggested retail price, making it an effective and affordable alternative to costly pharmaceutical formulas. As always, you can count on Biotics Research Corporation to offer superior nutritional products supplying “The Best of Science and Nature”.


For SIBO, specific botanical interventions are as good as or better than antibiotics!

Small intestine bacterial overgrowth (SIBO) results in chronic intestinal and extraintestinal symptomatology, adversely affecting patients’ quality of life. In this study, approved by the Johns Hopkins University Internal Review Board, researchers looked at the remission rate of SIBO using rifaximin (the most widely recognized antibiotic for SIBO) at 1200 mg daily vs. herbals; among them Oregano Oil, Thymus vulgaris, Yarrow, Artemisia and others. Patients positively diagnosed with SIBO by lactulose breath testing (LBT) were offered either rifaximin or herbal therapy for 4 weeks with repeat LBT post-treatment. Of the patients receiving herbal therapy, 46% had a negative LBT follow-up compared to 34% for rifaximin users. Additionally, of 14 rifaximin non-responders who followed up with herbal therapy, 8 (57.1%) had a negative LBT after completing the rescue herbal therapy. Of an additional 10 rifaximin non-responders offered triple antibiotics, 6 (60%) responded. The researchers concluded that herbal therapies are at least as effective as rifaximin for resolution of SIBO and appear to be as effective as triple antibiotic therapy for SIBO rescue therapy for rifaximin non-responders.

V. Chedid et al. Herbal Therapy is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth. Glob Adv Health Med. 2014 May; 3(3): 16-24.


Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

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