Vitamin D for chronic inflammatory rheumatic diseases (CIRD)?

by Biotics Research

Researchers studied a cross-section from the baseline visit of the CARMA (cardiovascular in rheumatology) project, a 10 year prospective study evaluating the risk of cardiovascular events in rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) patients, and non-CIRD patients who attended rheumatology outpatient clinics from 67 hospitals in Spain. 2,234 patients were assessed. Non-CIRD group was frequency matched by age with the joint distribution of the three CIRD groups included in the study. The aim was to evaluate the association between vitamin D status (25(OH)D) and the clinical characteristics of patients with CIRD. Deficiency was defined as 25(OH)D levels <20 ng/ml. Patients with CIRD had lower 25(OH)D levels than those form the non-CIRD controls. Globally, vitamin D deficiency was detected in 40.5% of patients with RA, 39.7 % of patients with AS, 40.9 % of patients with PsA, and 26.7% of those with non-CIRD. Overall, researchers found that RA patients have a high risk of vitamin D deficiency, in spite of presenting low-to-moderate disease activity. They concluded that clinicians must monitor the levels of vitamin D at baseline and during follow-up and supplement vitamin D if any deficiency is detected.

A. Urruticoechea-Arana, et al. Vitamin D deficiency in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study. Arthritis Research & Therapy Aug 15, 2015

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