From Biotics

Supplement FAQ: BioDrive®

Why you may need BioDrive®:

As women age, hormonal imbalances and fluctuations may lead to fatigue and waning libido.  The topic of women’s sexual health has received little study in comparison to the plethora of studies dedicated to male sexual function.  Further compounding this lack of information are studies that indicate that female libido is far more complex than male libido, which can be primarily linked to testosterone levels. One study tested more than 1000 women over 45 years of age and found that serum levels of testosterone and other sex hormones had no link with the degree of sexual desire – ruling out the possibility of a simple diagnostic blood test for women.  Furthermore, some women may not recognize declining libido as such, and instead blame age, stress, or overwhelming fatigue for their impaired sexual function.

Why your healthcare practitioner recommends BioDrive® from Biotics Research:

Formulated in conjunction with Dr. Michelle Pouliot, BioDrive® is a proprietary herbal blend, containing Rhodiola rosea extract for adrenal support, Turnera diffusa (an ancient aphrodisiac), Urtica dioica extract, an aid to limiting SHBG (sex hormone binding globulins), and Ginkgo biloba and Panax quinquefolia for increasing circulation to the extremities, including the sex organs.  In an evaluation using BioDrive®, 12 of 17 women (71%) who responded to a survey reported that they had greater interest in sex.  Of the twelve positive survey responders, ten said that they were more easily aroused, eleven indicated more pleasure with intercourse, eight reported an improved ability in achieving orgasm, and five reported increased intensity of orgasm.  Some patients on SSRI’s, which have a known effect on libido, have found BioDrive® to be very helpful.

Click here to download the Supplement FAQ about BioDrive® from Biotics Research in a printable PDF.


Supplement FAQ: BioPause-AM® & BioPause-PM®

Why you may need BioPause-AM® & BioPause-PM®:

For women, the aging process may not only mean the acquisition of laugh lines and grey hairs, but it may be associated with often debilitating symptoms and physical changes, commonly including: fatigue, hot flashes, night sweats, loss of libido, mood alterations, vaginal dryness, sleep disturbances, musculoskeletal changes, altered metabolism, and irregular or absent menstrual periods.  To further complicate matters, there is not a universal treatment for addressing these indications because no two women share identical symptoms nor do they respond similarly to existing therapies.  For this reason, your healthcare provider may choose to categorize each woman’s complaints and address them individually for a unique and personalized approach.  Dr. Michelle Pouliot, in conjunction with Biotics Research, has formulated and clinically evaluated key products for the support of women’s health, including  BioPause-AM® and BioPause-PM®.

Why your healthcare practitioner recommends BioPause-AM® & BioPause-PM® from Biotics Research:

Biotics Research’s line of women’s products are complex herbal formulations designed to support healthy female functioning.  They are effective individually or in combination.

BioPause-AM® is designed to address hot flashes and their associate palpitations often experienced during menopause. The adaptogenic properties of BioPause-AM® assist with fatigue and menstrual irregularities that are often reported by women. Clinically, women report less anxiety, more energy, and improved daytime mental clarity as a result of taking BioPause-AM®.

BioPause-PM® is formulated to assist women in getting the rest they need during their transitional phase of life. BioPause-PM® addresses such complaints as night sweats, anxiety and restlessness that often preclude a restful and rejuvenating sleep. Clinically, women taking BioPause-PM® report a reduction of anxiety and improved sleep quality.

Click here to download the Supplement FAQ about BioPause-AM® & BioPause-PM® from Biotics Research in a printable PDF.


Supplement FAQ: Bio-Allay®

Why you may need Bio-Allay®:

It has been said that our modern society can be termed an “Inflammation Nation”, with the vast majority of people living with some type of physical discomfort. Bio-Allay® contains a proprietary combination of three unique herbal extracts; White Willow (Salix alba), Devil’s Claw (Harpagophytumprocumbens), and Boswellia (Boswellia serrata gum) which collectively support comfort levels and promote enhanced activities of daily living. White Willow bark was the original source for the salicylates needed for the chemical manufacture of acetylsalicylic acid (aspirin), but clinicians should not be remiss in believing that White Willow is synonymous with acetylsalicylic acid. White Willow salicyclates have demonstrated inhibition of COX-2 transcription, a feature not noted in acetylsalicyclic acid. Additionally, anticoagulant and antiprostaglandin actions associated with acetylsalicyclic acid are not present with White Willow extract. Devil’s Claw has a long history of use for the support of musculoskeletal complaints.

Why your healthcare practitioner recommends Bio-Allay® from Biotics Research:

Over 12 clinical trials have been published on its use and all have found Devil’s Claw to be clinically valuable. Boswellia shows anti-inflammatory actions via the inhibition of 5-lipoxygenase, with no apparent effect on cyclooxygenase. Clinical studies have demonstrated that Boswellia was able to reduce swelling while increasing comfort, joint flexion, and walking distance in patients with wear and tear damage of the knees. Bio-Allay® is another fine example of leading-edge nutritional supplementation available exclusively from Biotics Research Corporation. The benefits from taking Bio-Allay® can often be noted within the first few doses, making it an excellent product to use with patients experiencing physical discomfort. Bio-Allay® is a safe and natural alternative to over-the-counter products, however it should be avoided by patients with a known sensitivity to aspirin or salicylates. As always, Biotics Research Corporation brings you “The Best of Science and Nature.

Click here to download the Supplement FAQ about Bio-Allay® from Biotics Research in a printable PDF.


Management of Pain and Inflammation

As one of the immune system’s response to infection or irritation, inflammation is the body’s means of eradicating the offending culprit. It is a multifaceted biological response of the vascular tissues to harmful stimuli, in which a complex innate cascade is initiated. This innate cascade is both cellular and exudative in nature, and is a protective mechanism by which the body attempts to remove the injurious stimuli, as well as to initiate the healing process. Although protective, a chronic or unceasing inflammatory response may eventually lead to a host of associated disease pathogenesis, including among others, atherosclerosis, rheumatoid arthritis, and periodontal disease. Therefore, limiting or “down-regulating” the inflammatory response may be desirable in certain situations.

As a part of the healing process, inflammation is normally closely regulated by the body. However, as noted above, excessive inflammation may result in an “inflammatory-fibroproliferative response” which can in turn generate unwanted health consequences, including advanced atherosclerotic lesions.[1] Dietary intake can also exacerbate the inflammatory response, especially when the diet consists of pro-inflammatory foods, including simple sugars and high-fat foods. These foods are well recognized as components that promote inflammation. Research has clearly demonstrated that n-6 fatty acids enhance carcinogenesis, whereas n-3 fatty acids are inhibitory to carcinogenesis. Consequently, to accelerate the healing process and to diminish inflammatory responses these type foods should be avoided. Likewise the omega-6 family of fatty acids should also be reduced or eliminated from the diet to the extent possible, as these fatty acids are inflammation promoters. In particular; linoleic acid (LA) and arachidonic acid (ARA) from the n-6 family should be limited in the diet as these fatty acids contribute to an inflammatory state. LA increases inflammation by a number of mechanisms, including the activation of NF-KappaB.[2] When acute inflammation becomes chronic, tissue healing cannot occur.[3]

Six of the ten leading causes of death in Americans are coronary heart disease, cancer, stroke, diabetes mellitus, atherosclerosis, and chronic liver disease and cirrhosis,[4][5], [6] all of which have been previously described as inflammatory in nature. A variety of dietary factors play a significant role in creating a “diet-induced proinflammatory state”. As previously mentioned degenerative inflammatory diseases are promoted by dietary imbalances.5 A diet rich in vegetables, fruits, and the proper fats can prevent a host of proinflammatory degenerative diseases; now a well accepted fact. Nearly all degenerative diseases have the same underlying biochemical etiology, that is, a diet-induced proinflammatory state. Optimal EFAs® provides a blend of essential fats in ratios deemed optimal.[7]

Natural anti-inflammatory agents such as bromelain, papain, trypsin and alpha-chymotrypsin, such as that contained in Intenzyme Forte™ can aide in reducing the excess inflammation correlated to pain perception. Other agents, such as NF KappaB inhibitors may be utilized in conjunction with Intenzyme Forte™ to further downreguate the inflammatory process. KappArest™ contains a number of these inhibitors, including tumeric (curcuminoids), boswellia, ginger and rosemary. In addition to these, analgesic ingredients, such as those in Bio-Allay® can also assist in pain modulation for these patients. These analgesic compounds include White Willow, Devil’s Claw, and Boswellia. Furthermore, flavonoid compounds are very beneficial mediators of the release of proinflammatory cytokines.[8] BioFCTS™ offers a concentrated source of flavonoids, including green tea, quercetin and vitamin C.


[1] Seaman DR. The diet-induced proinflammatory state: a cause of chronic pain and other degenerative diseases? JMPT. 2002 25(3):168-179.

[2] Rusyn I, et al. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis. 1999 Nov;20(11):2095-2100.

[3] Sedgwick A, Willoughby D. Initiation of the inflammatory response and its prevention. In: Bonta I, Bray M, Parnham M, editors. Handbook of Inflammation. Vol 5: The pharmacology of inflammation. New York: Elsevier; 1985. p. 27-47.

[5] Surgeon General’s Report on Nutrition and Health. US Department of Health and Human Services. Pub. No. 88-50211. Washington: US Government Printing Office, 1988. p. 2-4.

[6] Famighetti R, McGeveran W, Wiesenfeld L, Ellis B, Friedlander M, O’Malley M. The world almanac and book of facts. Mahwah (NJ): World Almanac Books. 1997 p. 964.

[7] Vasquez A. Reducing Pain and Inflammation Naturally Part I: New Insights into Fatty Acids Biochemistry and the Influence of Diet. Nutritional Perspectives. Oct 2004 27(4):5-14.

[8] Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol. 2005 August; 145(7):934–944.


Rachel Olivier, MS, ND, PhD

Dr. Rachel Olivier serves as a Physician Advisor for Biotics Research Corporation, a position she has held for over eleven years. As a Physician Advisor she serves to both educate and provide professional leadership for physicians and practitioners, in an effort to improve product understanding. In this capacity she serves as the main consultant, advisor and technical expert for health care practitioners. She also prepares and executes training seminars, and provides training and product support material for practitioners and members of the sales team, as well as writes technical and scientifically oriented papers for journals and trade magazines, and product literature updates. She holds a Masters degree in Molecular Biology from University of Southwestern Louisiana (currently the University of LA), along with a traditional Naturopathic Degree from Honolulu University, and a PhD in nutrition from California University.  She can be contacted at 800-231-5777 or via the website at


Supplement FAQ: Sculacia®

Why you may need Sculacia®:

In recent years, the safety of pharmaceutical joint pain formulas has been questioned and has resulted in doctors looking for effective, natural answers to support their patients’ needs. Sculacia® is such a product. Supplying a patented, proprietary, all-natural blend of Sculletaria baicalensis and Acacia catechu herbal extracts, Sculacia® inhibits the cascade of pro-inflammatory mediators. The efficacy of the Sculacia® formula was established in a clinical double blind study, where significant improvement was documented for joint comfort, stiffness and function, as compared to placebo.

Why your healthcare practitioner recommends Sculacia® from Biotics Research:

Sculacia® is yet another fine example of the leading-edge nutritional supplements that are available exclusively from Biotics Research Corporation.  The beneficial effects from taking Sculacia® will be noted by the end of the first bottle, and frequently they can be noted within the first few doses, making this an excellent product to use for those suffering from joint discomfort.  Effective as a stand-alone product, Sculacia®is also an excellent adjunct to use with chondroprotective products such as Purified Chondroitin Sulfates and ChondroSamine Plus®, allowing patients to achieve significant impact almost immediately, while they wait for the accumulative effect of the chondroprotectives to be established.  Sculacia® carries a low suggested retail price, making it an effective and affordable alternative to costly pharmaceutical formulas. As always, you can count on Biotics Research Corporation to offer superior nutritional products supplying “The Best of Science and Nature”.

Click here to download the Supplement FAQ about Sculacia® from Biotics Research in a printable PDF.


Supplement FAQ: Optimal EFAs Caps®

Why you may need Optimal EFAs Caps®:

The consumption of Essential Fatty Acids (EFAs) is absolutely required for optimal health. In addition to being required for the formation of cell membranes, EFAs are essential for cerebral and neurological development and functioning. EFAs are also required for the production of hormone-like substances called Eicosanoids which are collectively responsible for regulating blood pressure and blood viscosity, along with immune and inflammatory responses. EFA imbalances are very common in modern societies, particularly for/in those whose diet is over-reliant on grains or in those who consume an abundance of processed foods containing artificial ingredients or hydrogenated fats, in other words the Standard American Diet (SAD). EFA deficits generally occur in combination, therefore supplementation with a balanced combination of EFAs makes sense. Mood and memory alterations, neurological issues, high blood pressure, coagulation issues, altered cholesterol panels, slow wound healing, impaired growth, immune and mental deficiencies, and poor vision have all been clinically associated with EFA deficiency. Deficiencies are also associated with a wide variety of dermatological complaints – everything from dry or itchy skin, eczema, psoriasis, hemorrhagic, scaly or idiopathic dermatitis, folliculitis, skin atrophy, and edema. Children, seniors, and those consuming altered or unbalanced diets are especially prone to EFA deficiency.

Why your healthcare practitioner recommends Optimal EFAs Caps® from Biotics Research:

Optimal EFAs Caps® was strategically formulated with noted researcher and author, Dr. Alex Vasquez, DC, ND, DO to provide an ideal balance of Omega-3, -6, and -9 fatty acids. Supplied as a unique blend of the highest quality fish, flaxseed, and borage oils that are tested for purity, collectively they provide ALA, EPA, DHA, GLA, and Oleic Acid in ratios that are optimal. Available as easy to take capsules or in a naturally flavored liquid formula, Optimal EFAs® are available exclusively through Biotics Research. As always, you can count on Biotics Research to offer superior nutritional products supplying “The Best of Science and Nature”.


Click here to download the Supplement FAQ about Optimal EFAs Caps® from Biotics Research in a printable PDF.


Supplement FAQ: KappArest™

Why you may need KappArest™:

Pain is one of the many things we humans share. And though pain may be subjective (we cannot judge each others level of it), inflammation is not. Inflammation is our body’s response to injury, real or perceived.

The inflammatory cascade is triggered by environmental stimuli such as injury, food or environmental allergens, viral infections, exposure to toxins and emotional stress, or poor diet. This leads to the activation of something called NF-KappaB, a protein complex that acts as an intracellular “amplifier” to promote the production of direct mediators of inflammation. These include such compounds as cytokines, prostaglandins, leukotrienes, nitric oxide and free radicals. If NF-KappaB is left unchecked, it can lead to pain, inflammation and even insulin resistance, and cardiovascular and autoimmune disorders. Unfortunately, inflammation has become prevalent in our society, largely sue to the pro-inflammatory nature of the Standard American Diet (SAD) and the nutritional deficits resulting from it, our high stress lifestyles, and constant environmental insults.

Why your healthcare practitioner recommends KappArest™ from Biotics Research:

Formulated in conjunction with Alex Vasquez, DC, ND, DO, KappArest™ was designed to inhibit the production of NF-KappaB. KappArest™ has been shown to have a positive impact on inflammatory mediators, and has demonstrated it ability to modulate inflammatory responses. Optimal EFAs® and Bio-D-Mulsion Forte® are two additional products available from Biotics Research Corporation that are commonly used in conjunction with KappArest™ for their synergistic action in downregulating pro-inflammatory mediators that impact systemic inflammation. Once again, Biotics Research Corporation brings you “The Best of Science and Nature.”

Click here to download the Supplement FAQ about KappArest™ from Biotics Research in a printable PDF.


Vitamin D Deficiency and Pain

There is mounting evidence in medical literature to support the link between Vitamin D deficiency and pain.

The December, 2003, Mayo Clinic Proceedings listed Vitamin D deficiency as one possible cause of persistent and vague musculoskeletal pain. An editorial in the same issue, titled “Vitamin D Deficiency: What a Pain It Is” presents the mechanism by which vitamin D deficiency leads to pain. Dr. Alex Vasquez summarized this mechanism in a November 2004, Nashua, NH lecture as follows “…1) vitamin D deficiency causes a reduction in calcium absorption, 2) production of parathyroid (PTH) hormone is increased to maintain blood calcium levels, 3) PTH results in increased urinary excretion of phosphorus, which leads to hypophosphatemia, 4) insufficient calcium phosphate results in deposition of unmineralized collagen matrix on the endosteal (inside) and periosteal (outside) of bones, 5) when the collagen matrix hydrates and swells, it causes pressure on the sensory-innervated periosteum resulting in pain.”

Since early 2000, numerous studies linking Vitamin D and pain have been published. Below are three studies I found to be very interesting.

In September 2010, the Scandinavian Journal of Primary Health Care published a study on Vitamin D status in patients with musculoskeletal pain, fatigue and headache. It was a cross-sectional descriptive study in a multi-ethnic general practice in Norway. A total of 572 patients referred by a general practitioner (GP) for an examination of hypovitaminosis D who reported musculoskeletal pain, headache, or fatigue were included in the study. Both genders and all ages were included. Vitamin D deficiency was found in 58% of patients. One-third of ethnic Norwegians had low vitamin D, while 83% of patients from the Middle East, Africa, and South Asia had low vitamin D with minimal seasonal variation of levels. One in two women from these countries had a vitamin D level below 25 nmol/L. Mean vitamin D level was lower in patients with headaches compared with patients with other symptoms. Some 15% of patients with low (< 50 nmol/L) vitamin D levels reported headaches, compared with 5% of those with normal vitamin D levels. Overall, the study showed a high prevalence of hypovitaminosis D in patients with non-specific musculoskeletal pain, headache, or fatigue.

An October 2010 study published in the International Journal of Rheumatic Diseases looked at the association between nonspecific skeletal pain and vitamin D deficiency. In patients with nonspecific skeletal pain the mean 25-(OH) Vitamin D was significantly lower and the proportion of 25-(OH) Vitamin D deficiency was significantly higher compared with controls. There was a significantly positive association between 25-(OH) Vitamin D deficiency and skeletal pain. The strength of association varied across the groups with strongest association observed with leg pain, followed by arthralgia and widespread pain. The results of this study indicated a positive association of vitamin D deficiency with a variety of nonspecific bone pain, particularly in women.

A study published in the March 2012 issue of Pain Management looked at Vitamin D Deficiency in Women with Fibromyalgia in Saudi Arabia. The objective of the study was to determine the prevalence of vitamin D deficiency among patients with fibromyalgia in a neurology clinic in the Kingdom of Saudi Arabia (KSA). The study was done at the neurology clinic of Bugshan Hospital, Jeddah, KSA, from January to April 2011. Thirty female patients were diagnosed with fibromyalgia according to new clinical fibromyalgia diagnostic criteria; their serum vitamin D levels were screened. Vitamin D deficiency is defined as <20 ng/mL, vitamin D insufficiency is defined as 21–29 ng/mL, and vitamin D sufficiency is equal to or >30 ng/mL. Thirty female patients were included in the study. The mean age was 34.56 ± 8.1 years. Mean vitamin D level was 4.76 ± 1.46 ng/mL. A significant negative correlation between vitamin D level and widespread pain index was found. Thirty percent of the patients were Saudi Arabian of whom 100% were veiled; 70% were non-Saudi Arabian of whom 47.6% were veiled and 52.4% wore long pants and/or full sleeved clothes. Vitamin D deficiency was equally prevalent among veiled (4.77 ± 1.37 ng/mL) and nonveiled (4.75 ± 1.68 ng/mL). Treatment with high-dose vitamin D resulted in clinical improvement in all patients. Effective treatment with high-dose vitamin D could lead to resolution of almost all symptoms.

It would make sense for those suffering persistent and vague musculoskeletal pain to check their Vitamin D status. If Vitamin D supplementation is needed, consider Bio-D-Mulsion® or Bio-D-Mulsion Forte®, the most convenient and cost effective way to raise your Vitamin D levels.


  1. Scandinavian Journal of Primary Health Care; Vol. 28, No. 3, Pages 166-171, September 2010
  2. International Journal of Rheumatic Diseases; Volume 13, Issue 4, pages 340–346, October 2010
  3. Pain Medicine;Volume 13, Issue 3, pages 452–458, March 2012
  4. Mayo Clinic Proceedings; Volume 78, Number 12, December 2003

Dennis McInerney, BS

Dennis McInerney has been the Southeast operations manager for Biotics Research Corporation since 1996. He is a graduate of Moravian College with a B.S. in Biology and Chemistry. He has over 45 years of experience in the health care field. His in-depth knowledge of biochemistry, physiology, pharmacology and how it pertains to nutritional supplementation has earned the respect as a highly regarded speaker and metabolic consultant by health care professionals of all disciplines. His experience includes several years as a research pharmacologist as well as a metabolic consultant. In 1998, Dennis founded the Health Resource Center, an educational company, dedicated to helping health care professionals understand and reverse the detrimental effects of the modern diet. Through seminars and workshops, the Health Resource Center provides functional nutritional information and the clinical tools necessary to successfully guide patients on a path to nutritional wellness.


Supplement FAQ: Intenzyme Forte™

Why you may need Intenzyme Forte™:

Health researchers are continually discovering that inflammation and its effects are at the root of many health problems.  In fact, it can be argued that most chronic health challenges involve some degree of inflammation and inflammatory markers.  But acknowledging inflammation and addressing it are two very different entities.  Since inflammation can be caused from such a wide variety of factors – everything from physical wear and tear, diet,environmental factors, genetics, and even local or systemic allergies, it can be difficult to find an easy way to address it.  Intenzyme Forte is a potent source of both plant and animal based enzymes that are an effective combination to break down the aberrant proteins associated with inflammation, hence the term “proteolytic enzymes”.  Proteolytic enzymes are an outstanding and highly effective remedy for systemic or localized inflammation and discomfort such as muscle soreness.  The key, however, is that in order to benefit from enzymes proteolytic actions; it must be taken on an empty stomach. If taken with food, the enzyme will work as a digestive aid instead.

Why your healthcare practitioner recommends Intenzyme Forte™ from Biotics Research:

Intenzyme Forte™ is a broad spectrum nutritional supplement capable of exerting influence over a variety of physiological and biochemical mechanisms, including: inflammatory processes, numerous pathways of protein metabolism, hormone processing, digestive processes, food sensitivities, immune system support, and healthy circulatory system support.  Intenzyme Forte™ also has the ability to break down mucous secretions as well. For over 30 years, thousands of healthcare practitioners have relied on the safe, effective, and reliable results that Intenzyme Forte™ has to offer.  As always, you can count on Biotics Research to offer superior nutritional products that supply “The Best of Science and Nature”.

Click here to download the Patient FAQ on Intenzyme Forte™ from Biotics Research in a printable PDF.



Supplement FAQ: Bio-FCTS™

Why you may need Bio-FCTS™:

 Bioflavonoids are a class of plant metabolites usually noted for their yellow color.  They are commonly used for their wide variety of biological properties.  While bioflavonoids are most commonly referred to for their potent antioxidant properties, they have also been noted to provide positive support for the mediation of allergic and inflammatory responses.  Components of  Bio-FCTS™ are known to support immune function and protect against capillary fragility.  People with less than optimal diets or those consuming certain classes of medications including barbiturates, oral contraceptives, antibiotics, corticosteroids, or hormonal replacement therapy may have increased needs for vitamin C and bioflavonoids.

Why your healthcare practitioner recommends Bio-FCTS™ from Biotics Research:

Bio-FCTS™ is a fortified bioflavonoid product available exclusively through Biotics Research Corporation. Each capsule contains 100 mg of quercetin, 75 mg of vitamin C, and 440 mg of a proprietary blend of buckwheat culture, green tea extract (40% catechins), citrus bioflavonoids, neonatal thymus (bovine), and neonatal spleen (bovine). Although bioflavonoids are present in all botanicals, fruits, and vegetables – Bio-FCTS™ contains potent concentrations of phytonutrients and glandular sources specifically known for their bioactivity.  Once again, Biotics Research Corporation brings you “The Best of Science and Nature”.


Click here to download the Patient FAQ on Bio-FCTS™ from Biotics Research in a printable PDF.


Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

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