AD

Omega-3 Fatty Acids Protect Cognitive Function in Aging Adults!

In neurodegenerative diseases such as Alzheimer’s disease (AD) or mild cognitive impairment (pre-dementia phase of AD) changes in cognitive function and memory decline occur quicker than in normal aging. In this study, researchers looked at the effects of 2,200 mg of Omega-3 (n3) fatty acids (FA) taken daily for six months on memory function. Using LOCATO, a robust and sensitive tool for assessing object-location memory (OLM) in older adults to evaluate the impact of n3-FA on memory and learning formation, they conducted a double-blind placebo-controlled proof-of-concept study. 44 healthy female participants (50-74 yrs) completed before and after OLM-task (testing). As secondary outcome parameters, performance in Rey Auditory Verbal Learning Test (AVLT), dietary habits, omega-3-index, and other blood-derived parameters were assessed. They received either n3- FA or placebo for 26 weeks. Omega-3 index increased significantly in the n3-FA group compared to placebo. Recall of object locations was significantly better after n3-FA supplementation compared to placebo, although the AVLT was not significantly affected. This study provides further evidence that n3-FA exert positive effects on memory functions in healthy older adults, and the findings suggest novel strategies to maintain cognitive function into old age.

Külzow N, et al. Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults. Journal of Alzheimer’s Disease. Feb 10 2016 doi:10.3233/JAD-150886

0

Pycnogenol® and Grape Seed Extract for Cognitive Function?

In this study, 44 subjects (55-70 yrs) with high oxidative stress were supplemented with Pycnogenol® daily for 12 months. Another group with comparable oxidative stress was followed as a reference group. Cognitive testing, including IQ Code, cognitive function and SBT were conducted using defined scales. Results after 12 months showed significant improvement in the supplemented group vs the reference group for all tests conducted. Researchers concluded that Pycnogenol® supplementation appears to improve cognitive function and oxidative stress in normal subjects between 55 and 70 years old.(1) Researchers at Mount Sinai School of Medicine and the University of Minnesota evaluated the ability of grape-derived polyphenols to prevent the generation of a specific form of β-amyloid (Aβ) peptide, a substance in the brain known to cause neurotoxicity associated with Alzheimer disease (AD). They administered grape seed extracts to mice genetically determined to develop memory deficits and Aβ neurotoxins similar to those found in AD. They found that the brain content of Aβ*56, a specific form of Aβ previously implicated in the promotion of AD memory loss, was substantially reduced after treatment. Their study corroborates other studies suggesting grape polyphenols may protect against cognitive decline in AD.(2, 3)

1. Belcaro G, et al. The COFU3 Study. Improvement in cognitive function, attention mental performance with Pycnogenol® in healthy subjects (55-70) with high oxidative stress. J Neurosurg Sci 2015;59: 437-46.
2. Lie P, et al. Grape Seed Polyphenolic Extract Specifically Decreases Aβ*56 in the Brains of Tg2576 Mice. Journal of Alzheimer’s Disease, Vol 26, No. 4.
3. Natural chemicals found in grapes may protect against Alzheimer’s disease. ScienceDaily, 18 July 2011

0

Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

Click here to subscribe to the The Bio-Blog via email!

Click here
to become our Fan on Facebook!