Nutritional Support for Digestive Health

by Rachel Olivier, MS, ND, PhD

Hypochlorhydria is defined as a decrease in the secretions of hydrochloric acid and pepsin from the parietal cells of the stomach. Poor digestion notably increases with advancing age, as a consequence of the age related decline in digestive enzymes, along with a lower production of acid by the parietal cells of the stomach.  In fact, low stomach acidity is found in greater than 50% of patients over the age of 60.  Without an adequate supply of digestive enzymes or hydrochloric acid production, food digestion is incomplete, which may initiate other problems such as allergies or small intestinal bacterial overgrowth (SIBO).  In addition to digestion, the age-related decline in enzymes can also lead to deficits in vitamins, minerals, and trace elements, all of which may potentially adversely affect immune system functioning, and subsequently overall health.

According to Web MD, approximately 20% of the American population experiences symptoms of heartburn on a weekly basis.  In addition to the discomfort involved, these people are at increased risk of for cancers of the throat and vocal cords.  Symptoms associated with the lack of digestive enzymes include gas, bloating, heartburn and indigestion, inflammatory conditions, vitamin deficiencies, and malnutrition, all of which mimic the symptoms of acid reflux or gastroesophageal reflux disease (GERD).  Even in the absence of symptoms many people can benefit by the use of digestive enzymes, as both digestion and nutrient utilization are enhanced.  Additionally, numerous diseases have been linked to low gastric acidity, some of which include asthma, gastritis, Lupus erythematosus, osteoporosis, psoriasis, food allergies, eczema, pernicious anemia, and celiac disease.

Nutritionally oriented doctors often recommend digestive enzyme products in an effort to promote digestion and enhance nutrient absorption.  Some factors that contribute to an inadequate production of digestive enzymes include the age-related lack of enzymes, use of antibiotics, consumption of refined foods, environmental toxins and overall poor health.

In addition to its digestive nature, gastric acid also plays a fundamental role in activating pancreatic proenzymes, such as chymotrypsinogen and trypsinogen, converting them to their active forms, chymotrypsin and trypsin, respectively.  Along with peristalsis, gastric acid prevents the growth of excessive bacteria in the small intestines, thus also contributing to the prevention of the development of SIBO.  A lack of digestive enzymes may result in inappropriately absorbed macromolecules as a result of incomplete digestion, resulting in food allergies, immune complex diseases, or toxic overload of the liver.

Biotics Research Corporation offers a number of products which may be utilized to aide in promoting stomach acidity and optimal digestion.  These products include Hydrozyme™, HCl Plus™, Betaine Plus HP™, Bromelain Plus™ and Bromelain Plus CLA™.  Hydrozyme™ and HCl Plus™ offer hydrochloride in the form of Betaine (beet) hydrochloride, while Bromelain Plus™ and Bromelain Plus CLA™ offer digestive capability in the form of bromelain, derived from pineapple.  The product Betaine Plus HP™ provides a high potency (HP) source of betaine hydrochloride (700mg/tablet) for those patients requiring more comprehensive digestive support.  For pancreatic support Bio-6 Plus™ may be utilized as a source of the pancreatic enzymes amylase, lipase and protease.  Finally, Beta Plus™ provides bile from non-GMO animals, which may be utilized as an adjunct for biliary support.


Addressing Digestive Health Naturally

by John Crescione, DC, DICS

While the mouth is actually first in line of the digestion process, the stomach is what most of us think about when we think digestion. Emotions, age, prescription drugs and the wrong foods can all interfere with the digestion process.


A quick review of the stomach reveals that stomach acid,or gastric acid is a digestive fluid, formed in the stomach and has pH of 1.5 to 3.5 and is composed of hydrochloric and large quantities of potassium(KCl) and sodium chloride (NaCl). The acid plays a key role in digestion of proteins, by activating digestive enzymes and making the eaten proteins more broken down so that digestive enzymes break down the amino acids.


Gastric acid is produced by cells lining the stomach,while stomach cells also produce bicarbonate, so that the stomach does not become too acidic. These cells also produce mucus, to prevent gastric acid from damaging the stomach. Cells in the beginning of the small intestine, or duodenum, produce large amounts of bicarbonate to negate any gastric acid that passes further down into the small intestine from the stomach.


There are 4 phases of stomach acid secretion.  The basal phase in which a small amount of acid is always being secreted into the stomach.The cephalic phase in which 30 percent of the total gastric acid secretions is stimulated by anticipation of eating, as well as the smell or taste of food. The gastric phase in which fifty percent of the total acid is secreted. Secretion is stimulated by distension(stretching) of the stomach and by amino acids present in the food. Then finally,the intestinal phase where the remaining portion of acid is secreted when chyme enters the small intestine


Achlorhydria, the absence of hydrochloric acid in the gastric secretions of the stomach, is generally thought of in the elderly. Clinical evidence is showing more and more issues with diminished or weakening Gasrtric acids in the middle age population as well as the elderly. This can potentially lead to problems as the antiseptic properties of the gastric acid and stomach lining are decreased meaning a greater risk of infections of the system,such as infection with Vibrio or Heliobacteri bacteria, as well as improper breakdown of foods entering the small intestine.


Acid Reflux (GERD) is generally thought of as a symptom of stress and improper digestion and too much gastric acid, when in reality it is usually a weakening of gastric acid.In Zollinger-Ellison syndrome and hypercalcemia, there are increased gastrin levels, leading to excess gastric acid production, which can cause gastric ulcers.


The clinician should always consider stomach acid, digestive enzymes,multi minerals and acidophilus in all conditions of the patients’ healthcare. Recommendations

for gastric acid weakness would include HCl-Plus or Betaine Plus HP.  To support the stomach, Gastrazyme, Intenzyme Forte Bromelain Plus CLA and Lactozyme® should be considered.


My upcoming webinar, “Superior Nutrition for Optimal Digestive Health” will help guide you to solve and unravel the symptoms of digestive problems as well as provide nutritional protocols for optimal digestive health. Click here to register!


Supplement FAQ: Beta-TCP™ & Beta Plus™

by Biotics Research

Beta-TCP™ & Beta Plus™


As a direct result of the Standard American Diet (SAD), gallbladder problems are rampant in modern society. Traditionally, many practitioners have supplemented those with gallbladder issues with products containing bile salts, such as Beta Plus™. While bile salts have helped a great number of patients support normal digestive processes, they do not benefit those patients without bile insufficiency. Some patients produce adequate levels of bile; however, the bile they produce is too thick and thus may result in biliary stasis. Intolerances for fried or fatty meals, gas, bloating, constipation, post-prandial referred pain to the scapula, etc. are all functional signs that biliary function may be altered. For over 10 years, Beta-TCP™ has been the supplement of choice for practitioners supporting biliary motility. Each tablet of Beta-TCP™ supplies 100 mg of organic whole beet concentrate (a natural source of betaine) combined with pancrealipase, taurine, vitamin C, as well as superoxide dismutase and catalase – two very important antioxidant enzymes. Conveniently dosed at 1 to 3 tablets per meal, Beta-TCP™ is available in bottles of 90 & 180 tablets. As always, you can count on Biotics Research Corporation to offer superior nutritional products supplying “The Best of Science and Nature”.



Click here to download a Supplement FAQ of Beta-TCP™ & Beta Plus™  from Biotics Research in a printable PDF.


Supplement FAQ: Gastrazyme™

by Biotics Research


Why you may need Gastrazyme™:

From a natural point of view, the gastrointestinal tract is considered one of the most important systems in the body. Maintaining a healthy digestive tract is paramount in achieving optimal health, as poor digestion can cause a multitude of seemingly unrelated problems. Nutritional health and gastrointestinal health are therefore closely correlated. Gastrazyme™ combines a number of nutritional components intend to support a healthy digestive system, including vitamin A, gamma orzyzanal, chlorophyllins, vitamin U complex, superoxide dismutase and catalase. Early studies recognized the effectiveness of raw cabbage juice in normalizing gastric and intestinal functioning. Glutamine and methionine derivates present in the juice are believed to be the active principals. Specific attention has ben focused on methionine S-methyl sulfonium (MMS) in the chlorintated form. Traditionally, this compound (MMS) has been referred to as “Vitamin U”, although it does not meet the classic definition of vitamin. MMS has a variety of documented effects including stimulating the formation of gastric mucous, serving as an antioxidant, and acting as a methyl donor for a variety of acceptors. One study concluded that MMS supported the normal healing process of the stomach following exposure to nonsteriodal anti- inflammatory agents (NSAIDS). Due to the high turnover rate of gastrointestinal mucosa, vitamin A need is significantly increased. Inadequate vitamin A status has also been correlated with impaired barrier function of the GI tract, as well as immune system impairment. Gamma Oryzanol is a naturally ocuring mixture of plant sterols and free transferulic acid esters derived from rice bran. It has marked antioxidant properties and has been shown to normalize intestinal function in animals subjected to chemical or physical stress, as well as those subject to sleep deprivation. Chlorophillin, a derivative od chlorophyll, is also a known antioxidant. In addition, it maintains the ability to bind divalent metal ions, and protect DNA against damage from heterocylic amines in vitro.


Why your healthcare practitioner recommends Gastrazyme™:

While there are many different GI formulas available commercially, only Gastrazyme™ provides such a unique blend of scientifically proven nutrients, most from their ideal, natural sources. Cabbage juice supplies vitamin U complex (as DL-methionine methysulfonium chloride). Mulberry leaves supply chlorophyllins and vitamin A is not only derived from rice bran oil, but is combined in our proprietary tableting base which creates a synergistic antioxidant effect. Gastazyme™ provides superior nutritional support for healthy gastrointestinal function.





Click here to download a Supplement FAQ of Gastrazyme™  from Biotics Research in a printable PDF.


Managing Indigestion and Gastro-Esophageal Reflux Disease Naturally

by Dennis McInerney, BS

Managing Indigestion and Gastro-Esophageal Reflux Disease Naturally

Proper digestion is a “North to South” process, meaning from mouth to colon. The six organs involved from a nutritional standpoint are; the stomach, pancreas, liver, gall bladder, small intestine, and colon. The best results are gained when you address nutritional therapies for digestive dysfunction in a “North to South” manner.

There are a number of factors that can lead to digestive dysfunction. The following are just a few. Chronic stress can shift the body toward sympathetic dominance and away from the normal parasympathetic control that is essential for proper digestion. This can lead to a disruption of stomach acid and enzyme production and interfere with peristalsis. Another contributor to digestive dysfunction is improper chewing, which leads to low saliva production, setting up an environment for candida and other forms of dysbiosis to be fed by undigested starch. Nutrient deficiencies, allergies, alcohol, medications, tissue damage, infection and age can also negatively impact digestive function by reducing hydrochloric acid production, damaging intestinal mucosa, creating “leaky gut”, impairing absorption, and inhibiting or stimulating peristalsis. Low stomach acid allows for the fermentation of carbs, which produces gas and bloating, the putrefaction of proteins, which produces sulfuric and other organic acids and the rancidity of fat, which creates tissue damaging peroxides.

Two common digestive health concerns are indigestion and gastro-esophageal reflux disease (GERD). Indigestion is a common problem that causes pain & discomfort in the upper abdomen with a feeling of fullness or bloating. Indigestion (dyspepsia) can occur after eating a meal, usually large meals but sometimes smaller ones as well. GERD has symptoms similar to indigestion, but also includes the reflux of stomach content past the lower esophageal sphincter and into the esophagus.

Common causes of indigestion and GERD include low stomach acid, overeating, poor food combining, eating too fast, eating fatty or greasy foods, overindulgence in alcohol, eating spicy foods, emotional trauma or nervousness, and medications (NSAIDs, antibiotics, corticosteroids, Fosamax & Xenical). Low stomach acid is often the “straw that breaks the camel’s back”, so to speak, that ignites the fire of indigestion and GERD.

Indigestion can be prevented by avoiding oily food, coffee, chocolate, spicy food, peppermint, & alcohol, decreasing meal size, eating slowly, getting regular exercise, losing weight if overweight, not eating before bed and avoiding late night snacks, and learning stress reduction techniques.

If low stomach acid is the cause, consider HCl-Plus, Hydrozyme or Betaine Plus HP from Biotics Research as a dietary supplemental source of hydrochloric acid..



“Why Stomach Acid Is Good For You” by Jonathan V. Wright, M.D. and Lane Lenard, Ph.D.

“Heartburn And What To Do About It” by James Balch, M.D. and Morton Walker, D.P.M.

“Drugs That Don’t Work And Natural Therapies That Do” by David Brownstein, M.D.



Adrenal Physiology & the Stress Response

by Loren Marks, DC, DACBN

Adrenal Physiology & the Stress Response

What drives exhaustion, fatigue, & Mal-adaptation?

Presented by Dr. Loren Marks

It is imperative to understand the pivotal role adrenal physiology plays,not only in the apparent stress we see in our patient population and perceive in our own lives, but the long term effects over-stimulation of the gland produces in chronic disease states.
An incalculable amount of human morbidity and perhaps mortality exists due to the failure of physicians to understand and effectively treat
“The chronic stress response.”

This academic and clinically based seminar will enhance your ability to manage the scourges of chronic stress. Improving clinical outcomes in this arena leads towards your expertise in stress management.

Dr. Marks will also demonstrate a few cases on how to utilize his IAT
technique. If you practice any form of muscle response testing
he will show you how to correlate the findings with laboratory analysis,
as well as produce enhanced clinical outcomes.
• Understand adrenal physiology and the stress response.
• How neurotransmitters interact with the HPA axis.
• Adrenal physiology is at the core of many illnesses; understanding its role in human health improves clinical outcomes in most disease states.
• Glucocorticoids, Mineralcorticoids, Androgens
• Differentiate short and long term stress
• DHEA, 7 Keto-DHEA, Cortisol and Pregnenolone
• Blood, urine, saliva, muscle testing… what are the benefits and limitations of these modes?
• Adaptogens and their role in stress management
• Salivary adrenal hormones… 3 basic phases you must understand to treat effectively.
• Many courses outline the stages of adrenal exhaustion; perpetuators of adrenal exhaustion however, are the keys to effective management and resolution of chronicity.
• Dr. Marks unique algorithm will show you how to unmask the drivers of chronic exhaustion.
• Dysglycemia and Emotional health are key players in the adrenal arena. What you must know to remove the chaos!
• Patients suffer untold manifestations from the chronic stress response.
• Understanding this material and translating it into practical use in your clinic is the purpose of this course.
• Nutritional protocols and expanded diagnostic testing will be discussed.

Event Date: December 14, 2013 – 9:00am – 5:00pm
Event Region: Biotics Corporate


The Lounge

99 Warren Street

New York, NY, 10007

United States

See map: Google Maps

Loren Marks, DC, DACBN

Dr. Loren Marks is 1984 graduate of New York Chiropractic College. He received his Diplomate in nutrition in 2003 from the American Clinical Board of Nutrition, has been in practice in NYC for 28 years, and has taught clinical nutrition for the past 18 years across the United States. He is the founder of Integrative Assessment Technique (IAT) and currently teaches this to health professionals. Dr. Marks is co-author of a chapter in Dr. Andrew Weil’s series of texts on Integrative Gastroenterology, written by Dr. Gerrard Mullin, and he co-authored a chapter in “Arachnoiditis, the Evidence revealed” by Dr Antonio



Supplement FAQ: Hydro-Zyme™

by Biotics Research


Why you may need Hydro-Zyme™:

Good health depends on adequate digestion. From a nutritional point of view, the level or quality of health can be traced to the level of digestive functioning. The stomach produces a variety of substances that promote digestion and assimilation; gastric juice contains hydrochloric acid and pepsinogens (precursors of the family of proteolytic enzymes called pepsins). Parietal cells produce both stomach acid and intrinsic factor, a protein required to bind vitamin B12 prior to its absorption in the small intestine. Not to solely single out vitamin B12, inadequate production of hydrochloric acid can result in impaired uptake or deficiency of all B-vitamins, potentially leading to muscle weakness and neurological deficit. Hydrochloric acid (HCl) is a strong mineral acid which functions to maintain gastric pH between 1.5 and 2.5. This acidity serves three important roles; low pH kills microorganisms in food, it activates pepsinogen, and it denatures proteins, making them more accessible to proteolytic degradation. While impaired digestion may result from mechanical means, such as improperly chewed food, it is far more likely to be the result of poor diet, nutritional deficiency (as a direct result of antacids and similar medications), or inadequate HCl production. Compounding this decline, the incidence of low stomach acid increases with age. Studies estimating it impacts 30-60% of people over the age of 50. Among other things, functional deficits of HCl have been associated with gas, bloating, indigestion, malodorous breath and sweat excretions, anemias resulting from nutrient deficiency, leaky gut, food allergies, joint inflammation, hair loss, and environmental sensitivities.

Why your healthcare practitioner recommends Hydro-Zyme™:

Hydro-Zyme™ is yet another unique product brought to you by Biotics Research Corporation. Specifically formulated to support optimal digestive functioning, each tablet of Hydro-Zyme™ supplies a balance mixture of vitamin B6, Betaine Hydrochloride, Glutamic acid, Ammonium Chloride, Pancreatin 4X, and Pepsin in our proprietary biologically active vegetable culture tableting base. The low cost and simple ease of use of Hydro-Zyme™ makes it a natural choice for practitioners to recommend for the support of optimal digestive function. As always, Biotics Research Corporation brings you “The best of Science and Nature”.



Click here to download a Supplement FAQ of Hydro-Zyme™  from Biotics Research in a printable PDF.


Iodine and Autoimmune Thyroid Disorders

by David Brownstein, MD

Autoimmune thyroid disorders (AIT) are occurring at epidemic rates.  This includes both Hashimoto’s and Graves’ disease.  My experience has shown that approximately 20% of my patients are suffering from autoimmune thyroid disorders. 

In order to formulate an effective treatment plan, it is important to understand the underlying causative factor(s) behind this rise.  On Wednesday, September 25th, I will be presenting a free webinar for Biotics Research that will review what autoimmune thyroid disease is, the mechanism behind it, as well as an effective treatment strategy.

Many health care professionals, both conventional and holistically oriented believe that iodine causes autoimmune thyroid disorders and the iodine should be avoided in those patients suffering from autoimmune thyroid illness.   Does iodine cause/worsen or treat/improve autoimmune thyroid disorders?  These questions will be answered during this webinar.  At the end of this webinar, the practitioner will be able to diagnose and treat autoimmune thyroid illness.     


Supplement FAQ: Thyrostim

by Biotics Research



Why you may need Thyrostim™:

The thyroid gland is actually a collection of individual glands called follicles. Here, newly synthesized hormone is secreted prior to release into the bloodstream. In general, thyroid hormones refer to T3 (triiodothyronine) and T4 (thyroxine). Though T4 is the main product, T3 is 3 to 4 times more active. T4 (with 4 atoms of iodine) is converted to T3 (with 3 atoms of iodine) via peripheral tissues, especially the liver and lung. Several factors, including low metabolic rate, falling blood pressure, and conditions that increase the need for energy such as a cold environment, hypoglycemia, pregnancy, or high altitude, stimulate the secretion of thyroid hormones. Varying degrees of low thyroid function are routinely detected by laboratory tests and other measures.

Why your healthcare practitioner recommends Thyrostim™ from Biotics Research:

The manufacture of thyroid hormones requires specific nutrients. Thyrostim™’s broad spectrum formula was designed to provide these key nutrients. Take iodine for example; the common form of iodine in foods is iodide. At maximal activity, the thyroid can contain up to a 300-fold greater concentration of iodide than blood levels. Cells oxidize iodide to organically bound iodine, which is then chemically combined with tyrosine, an amino acid that is a protein building block. Each molecule of thyroid hormone contains the equivalent of two tyrosine molecules. Many other key nutrients are supplied by Thyrostim™ as well, such as selenium and magnesium, which are essential for healthy thyroid function. As always, you can count on Biotics Research Corporation to bring you “The Best of Science & Nature”.


Click here to download a  Supplement FAQ of Thyrostim™  from Biotics Research in a printable PDF.


Manage the Thyroid, Treat the Patient

by William M. Kleber, DC, DABCI


If you have ever head me lecture on thyroid, my mantra is “Manage the Thyroid, Treat the Patient”. What I am trying to get across to other practitioners is that thyroid hormone imbalance is seldom an issue with the thyroid itself. The ability of the thyroid to produce appropriate amounts of hormone and to have that hormone successfully stimulate the nuclear receptor sites is a delicate balancing act which is influenced by many things. As we successfully evaluate and treat the patient, thyroid hormone production and its ability to stimulate appropriate receptor sites will improve. As improvement comes about, blood levels of thyroid hormone should be monitored as a measure of success in treating the patient.

Among the many things we need to consider when analyzing thyroid function include but are not limited to:

1)    Autoimmune disease –Hashimotos/Graves.

2)    Central regulation and proper communication within the hypothalamus/pituitary/thyroid axis.

3)    Proper peripheral conversion of T4 to T 3

4)    The possibility of elevated Reverse T 3 from high adrenal stress and the blocking of nuclear receptor sites that normally would be occupied by T3.

5)    The availability of primed receptor sites and the influence of retinoic acid on these receptor sites. This requires a healthy gut mucosa and Vitamin A.

6)    Heavy metal toxicity, the presence of xenobiotics and the ability of the body to detoxify.

7)    Methylation pathway defects may be influenced by genetics and need to be considered due to their influence on things like gene regulation, biotransformation, the building of immune cells, energy production and oxidation.


Replacing thyroid hormone in a patient with a high TSH for the rest of that patient’s life seems over simplistic. Get to the bottom of your patients condition and fix it. As you do, “Manage the Thyroid, Treat the Patient”.



Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

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