Manage the Thyroid, Treat the Patient

by William M. Kleber, DC, DABCI


If you have ever head me lecture on thyroid, my mantra is “Manage the Thyroid, Treat the Patient”. What I am trying to get across to other practitioners is that thyroid hormone imbalance is seldom an issue with the thyroid itself. The ability of the thyroid to produce appropriate amounts of hormone and to have that hormone successfully stimulate the nuclear receptor sites is a delicate balancing act which is influenced by many things. As we successfully evaluate and treat the patient, thyroid hormone production and its ability to stimulate appropriate receptor sites will improve. As improvement comes about, blood levels of thyroid hormone should be monitored as a measure of success in treating the patient.

Among the many things we need to consider when analyzing thyroid function include but are not limited to:

1)    Autoimmune disease –Hashimotos/Graves.

2)    Central regulation and proper communication within the hypothalamus/pituitary/thyroid axis.

3)    Proper peripheral conversion of T4 to T 3

4)    The possibility of elevated Reverse T 3 from high adrenal stress and the blocking of nuclear receptor sites that normally would be occupied by T3.

5)    The availability of primed receptor sites and the influence of retinoic acid on these receptor sites. This requires a healthy gut mucosa and Vitamin A.

6)    Heavy metal toxicity, the presence of xenobiotics and the ability of the body to detoxify.

7)    Methylation pathway defects may be influenced by genetics and need to be considered due to their influence on things like gene regulation, biotransformation, the building of immune cells, energy production and oxidation.


Replacing thyroid hormone in a patient with a high TSH for the rest of that patient’s life seems over simplistic. Get to the bottom of your patients condition and fix it. As you do, “Manage the Thyroid, Treat the Patient”.



Supplement FAQ: Meda-Stim™

by Biotics Research

Why you may need Meda-Stim™:

Abnormal levels of thyroid hormones are routinely detected by laboratory tests, but subjective indicators may give an accurate snapshot of impaired thyroid function as well. Symptoms may include, among others, weight gain, cold intolerance, dry skin, brittle nails, joint pain, mood alterations, memory loss, low blood pressure, and fatigue. Thyroid hormones refer to T4 (thyroxine) as the prime constituent, and T3 (triiodothyronine), which is 3 to 4 times more active than T4. Thyroid hormones regulate metabolism and energy balance, growth and development, and the activity of the nervous system. They stimulate carbohydrate and fat breakdown, increase protein synthesis, and increase the basal metabolic rate. The normal conversion of T4 to T3 is critically important for healthy thyroid function, and can be negatively impacted by depleted nutrient levels.

Why your healthcare practitioner recommends Meda-Stim™ from Biotics Research:

Meda-Stim™ was formulated by Dr. Gary Lasneski to provide nutritional support for healthy thyroid function, primarily by supplying nutrients that support the conversion of T4 to T3. They include essential micronutrients such as B vitamins, Iodine, Selenium and Zinc. Also included are supportive nutrients such as the amino acids L-Tyrosine and L-Glutathione, along with specific botanical support. Having been in the marketplace for over a decade, the clinical results for practitioners who utilize Meda-Stim™ for their patients speak for themselves. As always, Biotics Research brings you “The Best of Science and Nature”.


Click here to download a Supplement FAQ on Meda-Stim™ from Biotics Research in a printable PDF.


Supplement FAQ: B12-2000™ Lozenges

by Biotics Research

Why you may need B12-2000™ Lozenges:

Homocysteine is an amino acid found in the blood.  It is an intermediate that occurs when the body is low in certain factors that convert one much needed amino acid (methionine) to another (cysteine).  Studies have shown that too much homocysteine in the blood (plasma) is related to a higher risk of coronary heart disease, stroke, peripheral vascular disease and potentially many other conditions of chronic inflammation. Other evidence suggests that homocysteine may have a serious effect on atherosclerosis (hardening or narrowing of the arteries) by damaging the inner lining of arteries and promoting blood clots.  Homocysteine levels are strongly influenced by diet, as well as by genetic factors. The dietary components with the greatest effects are folate and vitamins B6 and B12.  Folate, B6 and B12 vitamins help break down homocysteine in the body and complete its conversion to cysteine. Several studies have found that higher blood levels of B12 and folate correlate to lower concentrations of homocysteine. Other recent evidence shows that low blood levels of these essential vitamins are linked to a higher risk of fatal coronary heart disease, stroke, Alzheimer’s disease and dementia.

Why your healthcare practitioner recommends B12-2000™ Lozenges from Biotics Research:

B12-2000™ Lozenges are a naturally flavored B12 lozenge that also contain synergistic levels of both vitamin B6 and folate, all of which are key cofactors needed to reduce homocysteine levels.  B12-2000™ Lozengesare an oral B12 supplement designed to dissolve in the patient’s mouth.  Do not chew them.  Studies have demonstrated that, if allowed to dissolve in the mouth, oral forms of vitamin B12 are extremely effective.  This allows the nutrients to by pass digestion and enter directly into the blood stream, similar to injections but without the needle.  Biotics Research Corporation leads the industry in product quality and effectiveness bringing “The Best of Science and Nature” to the consumer.


Click here to download the Patient FAQ on B12-2000 Lozenges™ from Biotics Research in a printable PDF.


Supplement FAQ: Biomega-3 Liquid™

by Biotics Research

Why you may need Biomega-3 Liquid™:

Omega 3 fatty acids are essential fatty acids, or healthy fats, that are required for a number of bodily processes.  The body can not manufacture omega 3 fatty acids from other nutrients, hence the ‘essential’ distinction.  In addition to their well known role in promoting heart health, omega 3 fatty acids serve a number of basic biological roles; they are crucial for the structure and function of cellular membranes, they play a role in cellular and neurological signaling, they act as hormone precursors, and they aide in the regulation of nutrient uptake and excretion at the cellular level.  On a globally functional level, they are key in reducing inflammation, supporting normal cholesterol and triglyceride levels, regulating brain and neurological function, and regulating gene expression.  Omega-3 fatty acid deficiency has been associated with a wide variety of health complaints including obesity, ADD, ADHD, and similar spectrum disorders, inflammatory disorders, adrenal and/or thyroid hypofunction, skin issues, including eczema, psoriasis, and generalized dermatitis, cardiovascular issues, cognitive breakdown, and autoimmune disorders.

Why your healthcare practitioner recommends Biomega-3 Liquid™ from Biotics Research:

While it is true that omega-3 fatty acids can be found in a variety of sources, most commercial ones are limited to comprising of fish oil or flax seed oil. Not all omega-3 fatty acids are absorbed equally though, and omega-3 fatty acids found in flax are not the same as omega-3 fatty acids found in fish oil. While the body does have the capability of converting linolenic acid to EPA and DHA, the process is highly ineffective and the health benefits noted in population studies over the consumption of fish oil has not been noted amongst flax-consuming populations. One of the valid concerns about using fish oil supplements however, is pollution and contamination. There are a lot of fish oil supplements on the market that contain environmental toxins and heavy metals. Additionally, the peroxide levels of many of the products that we have tested are high, indicating that rancid fish oil is routinely being marketed by some of our competitors. Biotics Research uses only small, deep, cold water fish such as anchovies and sardines to avoid toxins that are found in accumulation in larger fish, and a comprehensive microbiological and heavy metal screening is run on all lots of Biomega-3™ Liquid to ensure that our customers receive the finest quality marine lipids available. Biotics Research is dedicated to supplying “The Best of Science and Nature”.

Click here to download the Patient FAQ on Biomega-3 Liquid™ from Biotics Research in a printable PDF.


Developmental Disorders In Children – Is Methylation the Key?

by Court Vreeland, DC, DACNB

The first question is, ‘What is methylation?’ When we speak about methylation as it relates to the body, it is thought of as the process that regulates protein synthesis, genetic expression and many aspects of metabolism. Since the completion of the Human Genome Project in April 2003 there has been particular interest in the genes that control the activation of folate (folic acid, vitamin B9) from the diet. This is required so the body can methylate one necessary compound to convert it to another. Note that the terms folate and folic acid are not interchangeable. Folic acid is the form found in fortified foods and supplements, and folate is the form found naturally in foods. The body must activate folate, found in such foods as green vegetables, mushrooms, and some types of beans, so it can be used. In order to activate folate it is converted into 5-methyltetrahydrofolate or 5-MTHF. The gene that codes for the enzyme that facilitates this conversion is the 5-methylenetetrahydrofolate reductase  (5-MTHFR) gene.

This gene may be mutated so that a child is significantly less efficient at converting folate from their diet into the usable form in the body. If this occurs he is less efficient at regulating protein synthesis, genetic expression and other factors related to metabolism.

Much of the early research involving the MTHFR mutation surrounded its link with birth defects in babies or in elevated levels of an amino acid called homocysteine, which is associated with higher risk of blood clots, stroke, heart disease and Alzheimer’s disease. New research on methylation is showing the link may extend to disorders like depression, anxiety, bipolar disorder, schizophrenia and even autism, ADHD and other developmental disorders.

If you are concerned about your child’s status, a simple blood test is all it takes to determine if this genetic mutation is present. If it is, the answer is also quite simple. Since this gene controls how well your child converts folate/folic acid in his diet to the active form you have two options. The first is to give your child high doses of folic acid. This will ensure he converts enough to the active form to reduce risk. This may require 5-10mg or more per day. The other, and more favorable option is to provide a pre-activated folic acid supplement. This is often called methylfolate. The dosages required for this are much lower as it’s already in the usable and active form. Here, doses of 800-1,600mcg may be sufficient.  Methylation is the new frontier in functional medicine and knowing your child’s status may make a world of difference in many developmental conditions.

Court Vreeland, DC, DACNB

Dr. Court Vreeland completed his undergraduate work at Fairleigh Dickison University in Madison, New Jersey where he received a Bachelor of Science degree in biology with a minor in chemistry. He then attended Logan College of Chiropractic in St. Louis, Missouri where he completed his Doctor of Chiropractic Degree. Dr. Vreeland finished his Diplomate degree in chiropractic neurology in September of 2007. He has also completed courses in the Neurological Rehabilitation of ADHD and Other Learning Disabilities and in Vestibular Rehabilitation. Additionally, Dr. Vreeland has completed 100 hours of training in Applied Kinesiology and lectures regularly throughout the community and New England. He has lectured for continuing education credits for the Vermont Chiropractic Association as well as regularly holding seminars for manual therapists in New England.



Supplement FAQ: Aqueous Multi-Plus™

by Biotics Research

Why you may need Aqueous Multi-Plus™:

For the human body to complete all the tasks it has in a normal day, it must be given a wide and complex variety of vital nutrients. Taking a broad-spectrum multivitamin/multi-mineral formula may help ensure the presence of those essential nutrients necessary for thousands of metabolic reactions. A deficiency in any one essential vitamin or mineral causes breakdown of metabolic pathways and leads to decreased performance in energy, strength and cognitive functions and presents the very real danger of illness. Your body cannot make its own vitamins – you must get them through the food you eat. This holds particularly true for children who have greater demands for these nutrients as they are still growing and developing. Your child would need to consume at least 5-7 servings of fruits and vegetables a day to fulfill this requirement. For many different reasons, very few children can get all the vitamins they need from their diet. Additionally recent reports have shown that most fruits and vegetables today contain 50% to 75% less vitamins and minerals than they did 40 years ago, suggesting that the 5-7 servings actually needs to be increased. What child is capable of this? In view of all this, in 2002 the American Medical Association recommended that everyone should supplement with a daily multi-vitamin to guarantee that they get all the vitamins and minerals needed to stay healthy as they age.

Why your healthcare practitioner recommends Aqueous Multi-Plus™ from Biotics Research:

Aqueous Multi-Plus™ is a great tasting, easy to take liquid, multivitamin mineral formula with all the essential B vitamins (except folic acid), vitamins A, C, D and E with calcium, magnesium and other minerals, It is highly suitable for children and those adults who have difficulty swallowing tablets or capsules. Aqueous Multi-Plus™ exemplifies the type of innovation, consideration and quality you and your healthcare professional can expect from Biotics Research Corporation.

Click here to download the Patient FAQ on Aqueous Multi-Plus™ from Biotics Research in a printable PDF.

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Supplement FAQ: Bio-D-Mulsion Forte®

by Biotics Research

Why you may need Bio-D-Mulsion Forte®:

Vitamin D is an essential co-factor in bone health. Among several other properties, vitamin D promotes the absorption of calcium and phosphorus, both of which are needed for bone health. Additionally, vitamin D regulates blood serum levels of these two minerals to maintain adequate mineralization of bone, bone growth and bone remodeling. Researchers from the Harvard Medical School published results of a large-scale study in the American Journal of Clinical Nutrition in February of 2003, confirming that there was a significantly lower risk of hip fractures only in individuals with a higher intake of calcium coupled with a higher intake of vitamin D. Vitamin D also plays several other important roles in human health including regulation of hormonal functions, modulation of neuromuscular and immune functions, reduction of inflammation, maintenance of vascular integrity, and proper gene encoding.

Why your healthcare practitioner recommends Bio-D-Mulsion Forte® from Biotics Research:

Vitamin D deficiency is common in the US, and more common in the elderly. It is known that the farther away from the equator you live the more at risk you are. Even worse, a recent study found that approximately 70% of the population of Phoenix, AZ had sub-optimal levels of vitamin D. If you wear sunscreen of SPF 8 or more, it is very unlikely that your skin is able to convert sunlight into vitamin D at all. A report published by Danish researchers in March 2004 showed that daily supplementation of vitamin D can reduce the risk of bone fractures and osteoporosis. A recent study conducted at Children’s Hospital Boston, found that Bio-D-Mulsion Forte® was safe and effective for infants and toddlers. Bio-D-Mulsion Forte® was shown to be highly bio-available, as effective as the pharmaceutical preparations it was compared to, and easier to administer. Additionally, Bio-D-Mulsion Forte® is far more cost effective. Clinical studies have shown Bio-D-Mulsion Forte® to be safe and effective for healthy adults, infants and children, as well as for those suffering from prostate cancer. Bio-D-Mulsion Forte® employs Biotics Research’s unique, all natural micro-emulsification, which greatly enhances the uptake and utilization, and is especially important for those having impaired digestive function. Additionally, in a recent study of the vitamin D products tested, only Bio-D-Mulsion Forte®  met specified quality standards for label claim and dose to dose consistency. This is another example of leading-edge innovation from Biotics Research, bringing you “The Best of Science and Nature


Click here to download a Supplement FAQ on Bio-D-Mulsion Forte® from Biotics Research in a printable PDF.


Gluten and Sensitivities

by Rachel Olivier, MS, ND, PhD

Gluten is defined as a protein composite found in foods processed from wheat and related grain species, including barley and rye. The word Gluten is derived from the Latin gluten, meaning “glue”, due to its elastic nature. In breads and other pastries it is used as an aid to the rising process. It also aids in shape, and often exhibits a chewy texture.

In an opinion paper published last year in BMC Medicine 1, researchers described gluten sensitivity as a disorder distinct from celiac disease, in part because the intestine doesn’t appear damaged. Although about 1% of the population has celiac disease, celiac disease has been described as the “tip of the iceberg” for an “emerging problem…of a group of gluten-reactive patients, accounting for roughly 10% of the general population.”1 Because gluten is classified as GRAS (generally recognized as safe) gluten content in processed foods may not be specifically listed on labels. As an example barley malt may be an undocumented source of gluten. People react to gluten in different ways; some having severe immune reactions. Other reactions to gluten include intestinal problems, psychological problems, migraine headaches, psoriasis, osteoporosis, fibromyalgia, chronic fatigue, multiple sclerosis, etc. Many practitioners believe there are numerous disorders (>200) that are correlated with gluten sensitivity.

In patients with celiac disease, a gluten free diet can be very beneficial. However, this dietary regimen can be just as beneficial for those with gluten sensitivity. In people with gluten sensitivity the symptoms may be as severe as in those with celiac disease.

Supplements are often not considered when discussions of gluten arise. However, it is comforting to know that all products from Biotics Research are free of gluten.

1. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen K, Rostami K, Sanders DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012 Feb 7;10:13. doi: 10.1186/1741-7015-10-13.

Rachel Olivier, MS, ND, PhD

Dr. Rachel Olivier serves as a Physician Advisor for Biotics Research Corporation, a position she has held for over eleven years. As a Physician Advisor she serves to both educate and provide professional leadership for physicians and practitioners, in an effort to improve product understanding. In this capacity she serves as the main consultant, advisor and technical expert for health care practitioners. She also prepares and executes training seminars, and provides training and product support material for practitioners and members of the sales team, as well as writes technical and scientifically oriented papers for journals and trade magazines, and product literature updates. She holds a Masters degree in Molecular Biology from University of Southwestern Louisiana (currently the University of LA), along with a traditional Naturopathic Degree from Honolulu University, and a PhD in nutrition from California University.  She can be contacted at 800-231-5777 or via the website at


Supplement FAQ: St. John’s Forte™

by Biotics Research

Why you may need St. John’s Forte™:

 In today’s society, feelings of anxiousness and nervousness are quite common. Whether it’s due to poor lifestyle habits, such as poor diet and lack of sleep, or emotional or physical stress, patients are often left feeling listless or lethargic.

Why your healthcare practitioner recommends St. John’s Forte™ from Biotics Research:

St. John’s Forte™ supplies a synergistic combination of botanicals, vitamins, minerals and other active compounds documented to support normal mood, and providing a beneficial effect on anxiety and nervousness. St. John’s Wort (Hypericum perforatum L.) is classified as a cooling herb and has a long history of use in traditional Chinese medicine. Conventional use is focused on unwanted mood patterns. Active constituents include hyperforin and hypericin. Damiana (Turnera diffusa) is traditionally used to support the nervous, endocrine and reproductive systems, and is noted for benefits associated with anxiety and nervousness. Siberian Ginseng (Eleutherococcus senticosus) functions as an adaptogen and is considered an invigorating tonic. Thiamin is a required component in carbohydrate metabolism and Riboflavin is an important molecule in intermediary metabolism. Folate is provided, as low folate status has been associated with an elevated score on a depressive symptom questionnaire (PHQ score of ≥ 10). Niacin is a precursor to coenzymes NAD and NADP and aids in proper functioning of the nervous system. P5P (the active form of B6) is an important component in the synthesis of neurotransmitters including GABA, serotonin, dopamine, norepinephrine and epinephrine. B12 is involved in numerous enzymes as a required coenzyme and is essential for the transformation of neurotransmitters and the methylation of compounds in the brain. Biotin is an essential coenzyme for five carboxylasis; deficiency has been associated with depression and lethargy. Chromium is included for its potentiating action on peripheral insulin. Recent research suggests that magnesium levels may be involved in the mechanism for the progression of depressive mood or stress perception in relatively healthy adult women. Inositol, an essential component of every cell, is a key ingredient for the membrane lipid phosphatidylinositol, while Choline serves as a  precursor for the synthesis of acetylcholine and the membrane phospholipid phosphatidycholine, thereby serving to support cognitive function.

Click here to download the Supplement FAQ on St. John’s Forte™ from Biotics Research in a printable PDF.


Concussion in Youth Sports – Addressing Recovery NATURALLY

by Court Vreeland, DC, DACNB

Concussion, or mild traumatic brain injury (mTBI), is a growing concern in sports but particularly in youth sports. A concussion is defined as a reaction by the brain to a jolt or force that can be transmitted to the head by an impact or blow occurring anywhere on the body. Essentially, a concussion results from the brain moving back and forth or twisting rapidly inside the skull.1 Although the hallmark of concussion is classically considered loss of consciousness, most occur without such an event.

Each year, at least 1.7 million TBIs occur either as an isolated injury or along with other injuries and about 75% of those are concussions or other forms of mild TBI. Children are the most at risk group to sustain a concussion with nearly a half million emergency department visits each year for TBI in children aged 0 to 14 years.2

Children present a unique problem when evaluating for return to play and monitoring recovery. While children are often thought of as more resilient when it comes to health, there is evidence they actually take longer to recover from concussion.3 Additionally, the brain of a child is still developing. Differing maturation rates makes mTBI important to understand. Patient age and maturation may affect prognosis.4

The biologic response to concussion by the brain is defined by an energy crisis and a neuroinflammatory response. The most immediate response by the brain is a large increase in demand for energy in the form of glucose. However, this is coupled with a decrease in cerebral blood flow. This creates a paradox in which the demand for energy far exceeds the brain’s ability to supply it. As a result, a complex set of interactions is triggered eventually resulting in severe neuronal dysfunction or death.5 The neuroinflammatory response is characterized by changes in the integrity of the blood brain barrier and immune system activation. This immune activation is from both the peripheral immune system and the immune system in the brain. It is mediated by inflammatory molecules called cytokines.6

The goal of treatment initially should be rest and removal from activity. The length of time this will last depends on the severity of the injury. Additionally, every attempt should be made to supply the brain with as much fuel as possible. The child should be eating frequently and not skipping meals. Meals should consist of low glycemic fruits, vegetables and high quality protein and fat.

After the initial phase has passed, control of the neuroinflammatory response and repair of the blood brain barrier should begin. This may include supplementing with products like superoxide dismutase, lipoic acid, vitamin D, N-acetyl cysteine, or omega-3 fatty acids. The goal of these is to reduce inflammation and balance pro-inflammatory cytokine production with anti-inflammatory cytokine production. The above with also have a favorable impact on blood brain barrier integrity.


  3. McCrory P, Meeuwisse W, Johnston K, Dvorak J, Aubry M, Molloy M, Cantu R. Consensus statement on concussion in sport–the 3rd International Conference on concussion in sport, held in Zurich, November 2008. J Clin Neurosci. 2009 Jun;16(6):755-63.
  4. Toledo E, Lebel A, Becerra L, Minster A, Linnman C, Maleki N, Dodick DW, Borsook D. The young brain and concussion: imaging as a biomarker for diagnosis and prognosis. Neurosci Biobehav Rev. 2012 Jul;36(6):1510-31.
  5. Giza CC, Hovda DA. The Neurometabolic Cascade of Concussion. J Athl Train. 2001 Sep;36(3):228-235.
  6. Das M, Mohapatra S, Mohapatra SS. New perspectives on central and peripheral immune responses to acute traumatic brain injury. J Neuroinflammation. 2012 Oct 12;9:236.

Court Vreeland, DC, DACNB

Dr. Court Vreeland completed his undergraduate work at Fairleigh Dickison University in Madison, New Jersey where he received a Bachelor of Science degree in biology with a minor in chemistry. He then attended Logan College of Chiropractic in St. Louis, Missouri where he completed his Doctor of Chiropractic Degree. Dr. Vreeland finished his Diplomate degree in chiropractic neurology in September of 2007. He has also completed courses in the Neurological Rehabilitation of ADHD and Other Learning Disabilities and in Vestibular Rehabilitation. Additionally, Dr. Vreeland has completed 100 hours of training in Applied Kinesiology and lectures regularly throughout the community and New England. He has lectured for continuing education credits for the Vermont Chiropractic Association as well as regularly holding seminars for manual therapists in New England.



Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

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