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Misconceptions of the Low FODMAP Diet: Facts, Myths & Patient Impact

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Making Memories with Huperzine A

Blog_1.24.23Our central hub, the brain, is made up of billions of neurons that communicate to other parts of the body in order to carry out physical and mental activities. Chemical messengers (neurotransmitters) carry out and enhance communication between these neurons and other cells in the body. Billions of neurotransmitters work non-stop to keep our brains functioning. Everything from breathing and the heartbeat to learning, concentration and memory depends upon neurotransmitters. Neurotransmitters also help to regulate our mood.

Because neurons work constantly, they require more energy than other cells in the body. Consuming nutritious meals and snacks throughout the day helps supply the brain with the fuel it needs. When our neurotransmitter levels are compromised from poor diet, or increasing age, our mood and overall brain functioning are also compromised. This may result in brain fog, poor memory, and irritable mood in addition to problems concentrating or retaining information.

In addition to getting sufficient sleep, exercise, and eating nourishing meals throughout the day, some supplements may further support our brain health – most notably, Huperzine A, also known as HupA.

Huperzine A is the biologically-active compound isolated from the firmoss, Huperzia serrata, and has been indicated to have benefits in brain health. It is particularly known in the nootropic industry to enhance memory and cognition. In addition to improvements in memory, research indicates that Huperzine A has other brain-boosting benefits, including neuroprotective effects in traumatic brain injury and anti-depressant activity.

How it Works

Huperzine A works by inhibiting acetylcholinesterase (AChE), an enzyme responsible for breaking down the neurotransmitter, acetylcholine. Acetylcholine (ACh) neurotransmission is critical in learning, memory and attention, so offsetting its breakdown with Huperzine A has led to an increase in this key neurotransmitter. In addition, acetylcholine levels decrease as we age, exacerbating memory loss and reducing cognitive ability, so supplementing with Huperzine A may help maintain healthy levels of acetylcholine in the elderly.

Working in combination with Gingko biloba and acetyl-L-carnitine, Huperzine A has been shown to further increase acetylcholine levels, which promotes new brain cell generation and aids in neuroprotection. Huperzine A can, therefore, boost the brain’s ability to form, as well as recall, new memories.  

Neuroprotective Effects

Huperzine A can also reduce oxidative stress in the brain. Specifically, it prevents oxidave stress in cholingeric neurons, a nerve cell that primarily uses acetylcholine to send its messages. The more oxidative stress these neurons face, the faster they break down. Huperzine A has been shown to protect the cell’s mitochondria by reducing oxidative stress as well as regulating the metabolism of beta-amyloid precursor proteins.

It has also demonstrated cytoprotective effects, providing protection to cells against harmful agents. For example, it exerts effects on the nitric oxide-induced and glutamate-mediated neurotoxicity, further protecting the cell and helping keep it healthy and optimally functioning. Huperzine A treatment has also been found effective in alleviating neuroinflammation and oxidative stress following repetitive brain injury, and, thereby, improving brain function.

Cognitive Ability

As stated earlier, increased acetylcholine neurotransmission is essential for brain regions responsible for learning and memory. Huperzine A has been shown to reverse cognitive deficits in several animal models. In particular, patients with Alzheimer’s disease exhibited significant improvements in memory enhancement when receiving Huperzine A.

Mood Health

Research suggests the potential for Huperzine A in alleviating some mental health symptoms, and supporting overall mood health. In schizophrenic patients, cognitive improvements, such as clarity, were noted and, although hopeful, more research in this area is needed. A rat study suggested potential for Huperzine A to reduce symptoms of anxiety with its mechanism of action showing Huperzine A acting as a selective NMDA receptor antagonist.

Key Points:

As we age, cognitive decline seems inevitable. However, the following can help support a healthy brain:

  1. Physical and cognitive exercise. Exercise your body and mind regularly.
  2. Social engagement. Social contact with others helps support brain health, such as our emotional and psychological health.
  3. Balanced diet. Eating a nutritious diet replete with plant-based foods, and rich in antioxidants.
  4. Regular sleep. Sleep needs vary from person to person, but, on average, 7 hours is recommended.
  5. Stress reduction. Stress can elicit a cascade of physiological problems. Practice stress-reducing exercises such as breathing, meditation or cognitive behavioral therapy.
  6. Nutritional supplements. Although a variety of nutrients are considered brain-boosting, some foundational supplements include omega-3 fatty acids, vitamin D and antioxidants.

And for mood and memory’s sake, Huperzine A.

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