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The Personal Fat Threshold: a New Perspective on Type 2 Diabetes & Obesity

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Snooze, You Lose

iStock-1284882341The relationship between sleep and weight is a two-way street. Lack of sleep can lead to weight gain; weight gain can lead to lack of sleep. Take steps to break those tight links and your weight, energy, and overall health will improve.

Sleep Less, Weigh More

When you don’t get enough quality sleep, two major hormone pathways in the body are affected, and not in a good way. The pituitary gland, which acts as the master controller for all other hormones, is very sensitive to lack of sleep. If you’re getting the seven to eight hours of sleep most people need, the pituitary gland functions normally. While you sleep, it coordinates the release of growth hormones and thyroid hormones, for example, and suppresses the release of the stress hormone cortisol. But if you’re like a lot of other adults these days, you’re in a more or less constant state of partial sleep deprivation. According to the National Sleep Foundation, the average American today sleeps only about seven hours a night—and many sleep only five to six hours a night on a regular basis.

Chronic sleep deprivation leads to elevation of cortisol in the evenings, a time when levels should be diminishing. When cortisol levels are chronically high, so is insulin resistance, a key factor leading to weight gain and a sharply increased risk of type 2 diabetes. Chronic sleep deprivation also changes the release of growth hormone. Instead of sending out one large pulse of the hormone soon after you fall asleep, two smaller pulses are sent, one before you fall asleep and another after. This exposes tissues to growth hormone for a longer period and is probably a factor in reducing glucose tolerance.

People who get too little sleep tend to be heavier than those who sleep enough. To take just one research example, women in the long-running Nurses’ Health Study who slept on average 5 hours a night or less had a 15 percent greater chance of becoming obese over 16 years than women who slept on average seven hours a night. According to the CDC, 33 percent of people who sleep less than 7 hours a night are obese, while only 26.5 percent of people who sleep more than 7 hours a night are obese.

Why does lack of sleep make you gain weight? One big reason is that the hormones that control appetite are powerfully affected by sleep loss—they make you hungry! In fact, they make you hungrier than you should be relative to how much energy you’re expending by staying awake. Your level of the hormone leptin, which regulates how satiated you feel, drops markedly if you don’t get enough sleep, so you feel hungry even if you’ve eaten recently. At the same time, your level of the hormone ghrelin, which stimulates your appetite, goes up, making you feel even hungrier—and crave carbohydrates to satisfy your appetite. It’s not a lack of willpower that’s making you eat cookies late at night—it’s lack of sleep.

Another reason chronic lack of sleep causes weight gain is increased insulin resistance. The mechanism is complex, but when you don’t sleep enough, your cells can’t handle insulin well—the sensitivity of your fat cells to insulin can drop by as much as 30 percent. When your cells are resistant to insulin, your blood sugar goes up and your pancreas produces more insulin to overcome the resistance. But insulin is also your body’s fat-storing hormone, so that extra blood sugar gets carried off to be stored as fat. You gain weight and are at increased risk not only for type 2 diabetes but also for high blood pressure, heart disease, and cancer. The risk of type 2 diabetes is very real. According to the CDC, 11.1 percent of people who sleep less than 7 hours a night have type 2 diabetes, while only 8.6 percent of those who sleep more than 7 hours a night have the disease. 

Weigh More, Sleep Less

The weight-sleep equation goes the other way, too: being overweight or obese can keep you from getting enough sleep. Weight-related health issues such as sleep apnea, chronic obstructive pulmonary disease (COPD), and arthritis can keep you from sleeping well—you don’t get enough sleep even if you’re in bed for seven or eight hours or even longer. Poor quality sleep has the same effect on your weight as lack of sleep.

Obstructive sleep apnea, for example, is a very common cause of poor sleep quality, especially among adults who are overweight or obese. With obstructive sleep apnea, your airway collapses or is blocked while you sleep. When that happens, breathing becomes very shallow or even stops while you sleep—the pauses can last for just a few seconds to up to a minute or even longer. In severe sleep apnea, they can happen as often as 30 times or more in an hour. After a breathing pause, you usually wake up with a choking noise or snort. Often, you go back to sleep right away, without realizing you woke up. The poor quality of sleep leads to daytime sleepiness, putting you at risk for car crashes and workplace accidents. In the long term, obstructive sleep apnea can cause the same chronic illnesses that sleeping too little does, including high blood pressure, heart attacks, diabetes, and cancer. It’s also associated with cognitive and behavioral disorders.

Sleep apnea is a serious medical problem that can be treated with breathing devices such as positive pressure masks, but lifestyle changes, particularly weight loss, are key.

With COPD, shortness of breath can make sleep difficult. People who have COPD and are also overweight or obese have even more trouble sleeping, which in turn can make their COPD symptoms worse. Exercise has been shown to be very helpful for COPD, but it’s hard to exercise when you’re tired from lack of sleep. Losing weight can help improve sleep and raise energy levels. 

Painful joints from arthritis can keep you up at night. Anti-inflammatory drugs and pain medication may help with sleep, but they can also bring additional problems, such as digestive upsets and possible dependence. Just as being overweight or obese is a significant risk factor for developing arthritis, losing weight is one of the best remedies. That’s hard to do if lack of sleep is causing hunger and painful joints are limiting your activity, but the improvement in arthritis symptoms from weight loss can be significant.

Changing Direction

The two-way street of sleep loss and weight gain can be turned into a one-way street leading to better health. The key is putting the brakes on weight gain by finding ways to get more high-quality sleep. Medical issues that impact sleep, such as sleep apnea or pain, need to be addressed.. More often, the issue is simple lack of sleep. Work schedules and life issues can mean a solid night’s sleep is low on the priority list. When you move sleep up to the top of the list, however, you might be pleasantly surprised by how much your work and personal life improves. Being well-rested helps provide more energy and can improve your outlook on life in general. When that happens, the ability to make dietary changes and stay focused on healthy eating really improves.

Truly, if you snooze, you lose!

Related Biotics Research Products:


Alpha-Theta PM

Alpha-Theta Ultra PM

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